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A Novel Huperzine A-producing Endophytic Fungus NWUHS002 Isolated from Huperzia Serrata Trev.
Research Article | Published: 08 November 2024
Agricultural Science and Food Processing Volume 1, Issue 1, 2024: 21-28
Volume 1, Issue 1, Agricultural Science and Food Processing
Volume 1, Issue 1, 2024
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Xiyu Cheng
Xiyu Cheng
Beijing Jiaotong University, China
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Agricultural Science and Food Processing, Volume 1, Issue 1, 2024: 21-28

Free to Read | Research Article | 08 November 2024
A Novel Huperzine A-producing Endophytic Fungus NWUHS002 Isolated from Huperzia Serrata Trev.
by
Rongxing Liu Rongxing Liu 1
Yirui Zhao Yirui Zhao 1
He Wang He Wang 1
Hao Zhang Hao Zhang 1
Xizhen Yue Xizhen Yue 1
Hongwei Guo Hongwei Guo 1
Jinmei Luo Jinmei Luo 1
Bin Guo Bin Guo 1,2,3 *
1 College of Life Science, Northwest University, Xi’an 710069, China
2 Key Laboratory of Biotechnology of Shannxi Province, Xi’an 710069, China
3 Key Laboratory of Resource Biology and Biothchnology in Western China (Ministry of Education), Xi’an 710069, China
* Corresponding Author: Bin Guo, [email protected]
DOI: 10.62762/ASFP.2024.857122
Received: 27 September 2024, Accepted: 25 October 2024, Published: 08 November 2024  
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Abstract
Huperzine A is an important drug for Alzheimer’s disease (AD) treatment, which is mainly extracted from the medicinal plant Huperzia serrata (Thunb.) Trev (Huperzia serrata Trev.). In present study, a new endophytic fungus (NWUHS002) producing Huperzine A was isolated from the Huperzia serrata Trev. with a yield of 5.20 µg/g. NWUHS002 was identified as Staphylotrichum by morphology and internal transcribed spacer (ITS) sequence. The discovery of NWUHS002 in Huperzia serrata Trev. can be used for the breeding of high-producing Huperzine A strains and the study of Huperzine A biosynthesis.
Graphical Abstract
A Novel Huperzine A-producing Endophytic Fungus NWUHS002 Isolated from Huperzia Serrata Trev.
Keywords
huperzine A
alzheimer’s disease
Huperzia serrata Trev.
endophyte
Funding
This work was supported by the Natural Science Basis Research Plan in Shaanxi Province of China under Grant 2023-JC-YB-165, Key Research and Development Plan Project of Shaanxi Province under Grant 2018ZDXM-SF-016, Xi’an Beilin District Science and Technology Plan Project under Grant GX2346 and Shaanxi Institute of Basic Sciences Project under Grant 23JHQ056.
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Cite This Article
APA Style
Liu, R., Zhao, Y., Wang, H., Zhang, H., Yue, X., Guo, H., Luo, J., & Guo, B. (2024). A Novel Huperzine A-producing Endophytic Fungus NWUHS002 Isolated from Huperzia Serrata Trev.. Agricultural Science and Food Processing, 1(1), 21–28. https://doi.org/10.62762/ASFP.2024.857122
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