As a carrier of genetic information, the precise design and optimization of nucleic acid (DNA or RNA) sequences are of critical importance for the realization of specific biological functions. From synthesizing genes to designing novel nucleic acid drugs, from constructing efficient expression vectors to modifying microbial metabolic pathways, all are inseparable from the fine regulation of nucleic acid sequences. The primary purpose of nucleic acid sequence design is to generate new sequences tailored to specific requirements for gene expression, function prediction, drug development, and other applications. In this paper, we first review the theoretical basis of nucleic acid sequence desig... More >

This paper introduces a novel method for controlling a class of nonlinear non-affine systems with fractional-order dynamics, using an adaptive fuzzy technique. By incorporating a novel fractional update law in the design procedure, the controller can effectively suppress chaotic behaviour and smoothly track desired trajectories. The proposed method offers key advantages such as robustness against uncertainties, fast error convergence to the neighbourhood of zero, and satisfactory disturbance rejection performance. To demonstrate the capabilities of the proposed fractional controller, simulation results were conducted using Python on a fractional order Arneodo chaotic system. The results high... More >

Presents the inaugural editorial for this issue of the publication. More >